The ZPL command ^RF has 2 options that support EPC memory: ^RFo,f,b,n,m
m = Gen2 memory bank. The options for EPC are: E = EPC 96bit and 1 = EPC.
RZ Command Details
Memory differences between "E" memory bank and "1" when using the ^RF are displayed below:

When using memory bank "1" the user can access the CRC and Protocol Control bits. If they use Memory bank "1" and wish to write the EPC data only, then they need to start at block 2. If they try to write to block 0, they will get an error as they are attempting to overwrite the CRC and PC-bits. The protocol control bits is the area of memory that defines how big the EPC data is. To change the size of the Protocol Control bits, refer to Defining the Size of the EPC Data That Can Be Encoded for GEN2 RFID Tags.
When using memory bank "E" they can't access the CRC or Protocol Control bits and need to start their writing at block 0. This EPC memory is limited to 96bits.
For full details on the RFID ZPL command ^RF and programming examples, see the RFID Programming Guide.